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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
16/02/2016 |
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Data da última atualização: |
03/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
KIM, E. S.; SONSTEGARD, T. S.; SILVA, M. V. G. B.; GASBARRE, L. C.; TASSEL, C. P. V. |
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Afiliação: |
Eui-Soo Kim; Tad S. Sonstegard; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; Louis C. Gasbarre; Curtis P. Van Tassell. |
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Título: |
Genome-wide scan of gastrointestinal nematode resistance in closed Angus population selected for minimized influence of MHC. |
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Ano de publicação: |
2015 |
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Fonte/Imprenta: |
PLoS One, v. 10, n. 3, : e0119380, 2015. |
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Páginas: |
18 p. |
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Idioma: |
Inglês |
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Conteúdo: |
Genetic markers associated with parasite indicator traits are ideal targets for study of marker assisted selection aimed at controlling infections that reduce herd use of anthelminthics. For this study, we collected gastrointestinal (GI) nematode fecal egg count (FEC) data from post-weaning animals of an Angus resource population challenged to a 26 week natural exposure on pasture. In all, data from 487 animals was collected over a 16 year period between 1992 and 2007, most of which were selected for a specific DRB1 allele to reduce the influence of potential allelic variant effects of the MHC locus. A genome-wide association study (GWAS) based on BovineSNP50 genotypes revealed six genomic regions located on bovine Chromosomes 3, 5, 8, 15 and 27; which were significantly associated (-log10 p=4.3) with Box-Cox transformed mean FEC (BC-MFEC). DAVID analysis of the genes within the significant genomic regions suggested a correlation between our results and annotation for genes involved in inflammatory response to infection. Furthermore, ROH and selection signature analyses provided strong evidence that the genomic regions associated BC-MFEC have not been affected by local autozygosity or recent experimental selection. These findings provide useful information for parasite resistance prediction for young grazing cattle and suggest new candidate gene targets for development of disease-modifying therapies or future studies of host response to GI parasite infection. |
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Thesaurus Nal: |
cattle; genetic markers; heritability. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/139139/1/Cnpgl-2015-PlosOne-Genome-wide.pdf
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Marc: |
LEADER 02131naa a2200217 a 4500
001 2037193
005 2024-02-03
008 2015 bl uuuu u00u1 u #d
100 1 $aKIM, E. S.
245 $aGenome-wide scan of gastrointestinal nematode resistance in closed Angus population selected for minimized influence of MHC.$h[electronic resource]
260 $c2015
300 $a18 p.
520 $aGenetic markers associated with parasite indicator traits are ideal targets for study of marker assisted selection aimed at controlling infections that reduce herd use of anthelminthics. For this study, we collected gastrointestinal (GI) nematode fecal egg count (FEC) data from post-weaning animals of an Angus resource population challenged to a 26 week natural exposure on pasture. In all, data from 487 animals was collected over a 16 year period between 1992 and 2007, most of which were selected for a specific DRB1 allele to reduce the influence of potential allelic variant effects of the MHC locus. A genome-wide association study (GWAS) based on BovineSNP50 genotypes revealed six genomic regions located on bovine Chromosomes 3, 5, 8, 15 and 27; which were significantly associated (-log10 p=4.3) with Box-Cox transformed mean FEC (BC-MFEC). DAVID analysis of the genes within the significant genomic regions suggested a correlation between our results and annotation for genes involved in inflammatory response to infection. Furthermore, ROH and selection signature analyses provided strong evidence that the genomic regions associated BC-MFEC have not been affected by local autozygosity or recent experimental selection. These findings provide useful information for parasite resistance prediction for young grazing cattle and suggest new candidate gene targets for development of disease-modifying therapies or future studies of host response to GI parasite infection.
650 $acattle
650 $agenetic markers
650 $aheritability
700 1 $aSONSTEGARD, T. S.
700 1 $aSILVA, M. V. G. B.
700 1 $aGASBARRE, L. C.
700 1 $aTASSEL, C. P. V.
773 $tPLoS One$gv. 10, n. 3, : e0119380, 2015.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Florestas. Para informações adicionais entre em contato com cnpf.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Florestas. |
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Data corrente: |
15/09/2008 |
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Data da última atualização: |
15/09/2008 |
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Autoria: |
AIRA, M.; MCNAMARA, N. P.; PIEARCE, T. G.; DOMÍNGUEZ, J. |
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Título: |
Microbial communities of Lumbricus terrestris (L.) middens: structure, activity and changes through time in relation to earthworm presence. |
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Ano de publicação: |
2008 |
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Fonte/Imprenta: |
In: INTERNATIONAL COLLOQUIUM ON SOIL ZOOLOGY, 15; INTERNATIONAL COLLOQUIUM ON APTERYGOTA, 12., 2008, Curitiba. Biodiversity, conservation and sustainabele management of soil animal: abstracts. Colombo: Embrapa Florestas. Editors: George Gardner Brown; Klaus Dieter Sautter; Renato Marques; Amarildo Pasini. 1 CD-ROM. |
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Idioma: |
Inglês |
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Conteúdo: |
We studied the microbial communities (structure and activity) of the soil system formed by
middens of Lumbricus terrestris and the soil below and surrounding them, and the role of
earthworms in maintaining these structures through time. We set up an experiment in which
middens were either left (control) or removed from their original place (manipulated) and left in
a next area free of worms for 2 months. The transplanted middens were in areas with no evident
signs of earthworm activity (e.g. casts). We took samples of middens, soil below and soil
surrounding (control and manipulated) after 1 and 2 months of manipulation and analyzed the
phospholipid fatty acid (PLFA) profiles and measured respiratory fluxes of CO2 and CH4.
Microbial communities of middens clearly differed from those of soil below and surrounding soil
samples; further, in control middens changes in microbial communities were stronger than in
manipulated middens. Moreover, total PLFAs and bacterial PLFAs (gram negative and positive
bacterial PLFAs) were greater in manipulated than control middens, as well as organic C. This
suggests that earthworms may be competing with microorganisms for C sources, since in organic
C of middens with earthworms decreased with time. Fungi PLFAs were higher in middens and
increased in abundance over time, although abundance was not affected by earthworm
presence. Respiratory fluxes of CO2 were always higher in control middens, revealing the main
role of earthworms in enhancing microbial activity of middens MenosWe studied the microbial communities (structure and activity) of the soil system formed by
middens of Lumbricus terrestris and the soil below and surrounding them, and the role of
earthworms in maintaining these structures through time. We set up an experiment in which
middens were either left (control) or removed from their original place (manipulated) and left in
a next area free of worms for 2 months. The transplanted middens were in areas with no evident
signs of earthworm activity (e.g. casts). We took samples of middens, soil below and soil
surrounding (control and manipulated) after 1 and 2 months of manipulation and analyzed the
phospholipid fatty acid (PLFA) profiles and measured respiratory fluxes of CO2 and CH4.
Microbial communities of middens clearly differed from those of soil below and surrounding soil
samples; further, in control middens changes in microbial communities were stronger than in
manipulated middens. Moreover, total PLFAs and bacterial PLFAs (gram negative and positive
bacterial PLFAs) were greater in manipulated than control middens, as well as organic C. This
suggests that earthworms may be competing with microorganisms for C sources, since in organic
C of middens with earthworms decreased with time. Fungi PLFAs were higher in middens and
increased in abundance over time, although abundance was not affected by earthworm
presence. Respiratory fluxes of CO2 were always higher in control middens, revealing the main
role of earthworms in enhancing m... Mostrar Tudo |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02295naa a2200157 a 4500
001 1314794
005 2008-09-15
008 2008 bl uuuu u00u1 u #d
100 1 $aAIRA, M.
245 $aMicrobial communities of Lumbricus terrestris (L.) middens$bstructure, activity and changes through time in relation to earthworm presence.
260 $c2008
520 $aWe studied the microbial communities (structure and activity) of the soil system formed by middens of Lumbricus terrestris and the soil below and surrounding them, and the role of earthworms in maintaining these structures through time. We set up an experiment in which middens were either left (control) or removed from their original place (manipulated) and left in a next area free of worms for 2 months. The transplanted middens were in areas with no evident signs of earthworm activity (e.g. casts). We took samples of middens, soil below and soil surrounding (control and manipulated) after 1 and 2 months of manipulation and analyzed the phospholipid fatty acid (PLFA) profiles and measured respiratory fluxes of CO2 and CH4. Microbial communities of middens clearly differed from those of soil below and surrounding soil samples; further, in control middens changes in microbial communities were stronger than in manipulated middens. Moreover, total PLFAs and bacterial PLFAs (gram negative and positive bacterial PLFAs) were greater in manipulated than control middens, as well as organic C. This suggests that earthworms may be competing with microorganisms for C sources, since in organic C of middens with earthworms decreased with time. Fungi PLFAs were higher in middens and increased in abundance over time, although abundance was not affected by earthworm presence. Respiratory fluxes of CO2 were always higher in control middens, revealing the main role of earthworms in enhancing microbial activity of middens
700 1 $aMCNAMARA, N. P.
700 1 $aPIEARCE, T. G.
700 1 $aDOMÍNGUEZ, J.
773 $tIn: INTERNATIONAL COLLOQUIUM ON SOIL ZOOLOGY, 15; INTERNATIONAL COLLOQUIUM ON APTERYGOTA, 12., 2008, Curitiba. Biodiversity, conservation and sustainabele management of soil animal: abstracts. Colombo: Embrapa Florestas. Editors: George Gardner Brown; Klaus Dieter Sautter; Renato Marques; Amarildo Pasini. 1 CD-ROM.
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Embrapa Florestas (CNPF) |
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